I have fired 100 rounds through the PPQ 45 once before when I first bought it 4/2017. I cannot say for sure if I fired my reloads through the gun the first time. But it is what I usually do. This time I was using my reloads and I fired 29 rounds and 2 times it misfired and then the slide would not pull back. It was jammed really tight. I pulled for several minutes and hit the back of the slide with my palm and it finally fired. The second time I showed it to a range worker and he had to pull many times to finally release it. I then bought some factory rounds from the range and fired 30 rounds with no trouble at all. I think the slide is not going forward all the way but far enough to allow release of the firing pin with the trigger. Then being a double action only, the trigger needs to be reset by pulling the slide back, but it jams so the slide will not go back. But it does seem my reloads may be the cause, but I'm still not sure. At home I removed the barrel and put all my left over reloads, 71, into the barrel by hand. They all seem to fit properly without any tightness. I sent for an after market slide spring mainly for testing purposes. I have been reloading for over 15 years and almost never have problems with my reloads. I had some .45 round once that were just slightly too long for one of my pistols, but worked great in another one. I do not make "custom" reloads and do not load "hot" rounds.