I wear/carry mine without pants. 
In all seriousness, what works for one guy may not work for another. You'll need to try different carry locations, cant and ride height to see what combination works for you.
Personally, I use as much cant as I can get. Most retail holsters seem to offer cants up to 15° and some offer a little more. I make holsters (for myself) and after much experimentation, arrived at a carry location of about 2:30 and 35° of cant...I use these holsters for IWB carry. When using a retail holster, I carry OWB at the same location, but with less cant. These work for me. You'll need to experiment.
This carry location means I NEVER sit on/lean back on the pistol....its in front of my hip.....easy access, and again with the right ride height and cant, its absolutely comfortable.
In all seriousness, what works for one guy may not work for another. You'll need to try different carry locations, cant and ride height to see what combination works for you.
Personally, I use as much cant as I can get. Most retail holsters seem to offer cants up to 15° and some offer a little more. I make holsters (for myself) and after much experimentation, arrived at a carry location of about 2:30 and 35° of cant...I use these holsters for IWB carry. When using a retail holster, I carry OWB at the same location, but with less cant. These work for me. You'll need to experiment.
This carry location means I NEVER sit on/lean back on the pistol....its in front of my hip.....easy access, and again with the right ride height and cant, its absolutely comfortable.