Yes/no, but the problem is Walther engineers didn't make the slide beefy enough in certain corners. Slides should not break. Especially those on .22 caliber pistols. Zinc alloy is heavier than aluminum alloys and there is only so much a relatively weak .22 can cycle. 10 or 12 years ago I added weights to the slide until Remington Golden bullets wouldn't cycle it reliably. I think I added 43 grams...but don't really remember. The problem is....other ammo, especially some of the Winchester stuff won't cycle the stock slide. And, you cannot go by the velocity labeled on the box. That is rifle barrel length velocity to begin with which is faster than that achieved with a short barrel pistol. Then you can also fire similar velocity but different brand ammo out of the P22 and notice significant recoil differences. Rem golden bullets feel exactly like CCI mini mags and both work well.
The best long standing advice regarding .22 ammo, pistol or rifle, is to buy some boxes of fifty and test them. Some will function better than others in your firearm. But the bottom line with semi autos is the ammo has to be powerful enough to cycle the slide and eject the spent case.
You might go over to RimFireCentral and look at the MK IV section. Seems there has been quite a bit of discussion regarding the barrels shooting loose. But I haven't been following it to see if Ruger has sorted it.